CGD

CGD: phagocytes eat but can't kill (no NADPH, granuloma) leading to infections (pneumonia, skin) by catalase+ bugs (staph).


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  • CGD
  • aka: chronic granulomatous disease,
  • phagocytes eat but can't kill (no NADPH, granuloma) leading to infections (pneumonia, skin) by catalase+ bugs (staph).
  • infections (pneumonia, skin, abscess) by catase+ bugs, poor wound healing, diarrhea
  • hepatosplenomegaly, growth↓
  • granuloma, neutrophil fx tests (DHR, NBT) are negative
  • no NADPH (no burst), so phagocytes eat but can't kill (granuloma). Catalase+ bugs bcz there's background H2O2 even without NADPH