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CLL/SLL (smudge): lots of mature lymphocytes that suck (node++, IgG--/infection, AIHA) and that smudge cell
- CLL/SLL
- aka: small lymphocytic lymphoma, chronic lymphocytic leukemia,
- smudge
- lots of mature lymphocytes that suck (node++, IgG--/infection, AIHA) and that smudge cell
- sucky lymphocytes (infections, AIHA: anemia/tired), spleen++ (satiety)
- lymph node++, spleen++, liver++
- smudge cell, lots of sucky (IgG--, small, AIHA) mature lymphocytes (lymphocyte++) that are clonal (flow cyt), AIHA (anemia, lyse RBC, plt--, coomb+)
- mature B malignancy, Bcl-2 ++ = inhibit apoptosis
- palliative (rituximab, fludarabine, rad). Prognosis: low grade, 13q14 = good, trisomy 12 = bad
- since it's mature B gone bad, it's capable of autoimmune. Bcl stands for b cell leukemia/lymphoma
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