CLL/SLL

CLL/SLL (smudge): lots of mature lymphocytes that suck (node++, IgG--/infection, AIHA) and that smudge cell


Browse disease: Endocrine | Neuro | Renal | GI | Cardio | Respiratory | Hemonc
  • CLL/SLL
  • aka: small lymphocytic lymphoma, chronic lymphocytic leukemia,
  • smudge
  • lots of mature lymphocytes that suck (node++, IgG--/infection, AIHA) and that smudge cell
  • sucky lymphocytes (infections, AIHA: anemia/tired), spleen++ (satiety)
  • lymph node++, spleen++, liver++
  • smudge cell, lots of sucky (IgG--, small, AIHA) mature lymphocytes (lymphocyte++) that are clonal (flow cyt), AIHA (anemia, lyse RBC, plt--, coomb+)
  • mature B malignancy, Bcl-2 ++ = inhibit apoptosis
  • palliative (rituximab, fludarabine, rad). Prognosis: low grade, 13q14 = good, trisomy 12 = bad
  • since it's mature B gone bad, it's capable of autoimmune. Bcl stands for b cell leukemia/lymphoma