CML

CML: tired pt with basophilia and Bcr-Abl = t9; 22 = phil chr, tx w imatinib/gleevec (inh bcr-abl)


Browse disease: Endocrine | Neuro | Renal | GI | Cardio | Respiratory | Hemonc
  • CML
  • tired pt with basophilia and Bcr-Abl = t9; 22 = phil chr, tx w imatinib/gleevec (inh bcr-abl)
  • feels ill (tired, wt loss), spleen (satiety)
  • spleen↑
  • granulocyte↑ (PMN, baso, eo)↑, plt↑, phil chr (cytogen), Bcr-Abl (FISH, PCR), LAP↓ (not reactive)
  • Philadelphia = 9;22 = Bcr-Abl.
  • Imatinib/Gleevec (inh Bcr-Abl), other "tinib"s, SCT
  • SCT = stem cell transplant