Cholera

Cholera: severe diarrhea, rice water stools, vomiting, dehydration, dx w stool microscopy, tx w rehydration, doxycycline


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  • Cholera
  • severe diarrhea, rice water stools, vomiting, dehydration, dx w stool microscopy, tx w rehydration, doxycycline
  • severe diarrhea (secretory), rice water stools, vomiting, dehydration, hx of foreign travel
  • stool sample (curved gram neg rods)
  • vibrio cholera's AB toxin, A subunit (ADP-ribosylase) activates G protein leading to cAMP↑, causing secretion
  • rehydration, doxycycline
  • AB-toxin: A for ADP-ribosylation, B for binding