Myelofibrosis

Myelofibrosis (teardrop): fatigue, splenomegaly and teardrop cells


Browse disease: Endocrine | Neuro | Renal | GI | Cardio | Respiratory | Hemonc
  • Myelofibrosis
  • teardrop
  • fatigue, splenomegaly and teardrop cells
  • fatigue, splenomegaly (ab pain, satiety), bone/joint pain
  • extramedullary hematopoeisis (spleen++, liver++)
  • initially plt++ (megak++), then all lineages-- (plt--, WBC--, RBC--), teardrop (RBC squeeze thru fibrous marrow), nucleated RBC, marrow fibrosis, bone mottling
  • marrow txp, watch for AML