PBC

PBC: woman with fatigue, itch, darker skin, hepatomegaly, severe AP↑, anti-mitochondrial Ab, biopsy shows lymphocytes destroying small bile ducts


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  • PBC
  • aka: Primary biliary cirrhosis,
  • woman with fatigue, itch, darker skin, hepatomegaly, severe AP↑, anti-mitochondrial Ab, biopsy shows lymphocytes destroying small bile ducts
  • 95% are women, fatigue, itch, darker skin
  • skin hyperpigmentation, xanthelasma, hepatosplenomegaly
  • severe AP↑, GGT↑, anti-mitochondrial Ab, ANA, IgM↑, biopsy shows lymphocytes injuring small bile ducts
  • AI destruction of small bile ducts by T cells, results in cholestasis and cirrhosis
  • ursodiol, cholestyramine (for itch)