Aminoglycoside

Aminoglycoside: Tx: gram negs (pos if add b-lactam), aerobes only. Mech: inh initiation complex, need O2 for uptake, bac-cidal. SE: nephrotox, ototox. Fact: don't cross CNS, inh by Ca, Mg, named -mycins (vs -thromycins for macrolids).


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  • Aminoglycoside
  • Tx: gram negs (pos if add b-lactam), aerobes only.
  • Mech: inh initiation complex, need O2 for uptake, bac-cidal.
  • SE: nephrotox, ototox.
  • Fact: don't cross CNS, inh by Ca, Mg, named -mycins (vs -thromycins for macrolids).