Metformin

Metformin (Biguanide,): Tx: type 2 diabetes (first line), lower lipids & wt. Mech: inc liver insulin sensitivity, AMPK, gluconeo↓. SE: GI, B12↓, lactic acidosis, contraindicated in hep, cardio, renal dz or IV contrast.


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  • Metformin
  • aka: Biguanide,
  • Tx: type 2 diabetes (first line), lower lipids & wt.
  • Mech: inc liver insulin sensitivity, AMPK, gluconeo↓.
  • SE: GI, B12↓, lactic acidosis, contraindicated in hep, cardio, renal dz or IV contrast.