Propylthiouracil

Propylthiouracil (PTU,): Tx: hypothyroidism. Mech: inh thyroperoxidase (iodination Tg), 5'-deiodinase (T4→T3). SE: hepatotox, agranulocytosis. Fact: preferred for 1st trimester of preg.


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  • Propylthiouracil
  • aka: PTU,
  • Tx: hypothyroidism.
  • Mech: inh thyroperoxidase (iodination Tg), 5'-deiodinase (T4→T3).
  • SE: hepatotox, agranulocytosis.
  • Fact: preferred for 1st trimester of preg.