Trimethoprim

Trimethoprim (TMP,): Tx: UTI. Mech: DHF analogue = inh DHFR = anti-THF = inh dTMP synth. SE: anti-folate (megalobastic anemia), for pts tx w PCP (rash, hepatitis). Fact: combine w sulfonamides (TMP/SMZ).


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  • Trimethoprim
  • aka: TMP,
  • Tx: UTI.
  • Mech: DHF analogue = inh DHFR = anti-THF = inh dTMP synth.
  • SE: anti-folate (megalobastic anemia), for pts tx w PCP (rash, hepatitis).
  • Fact: combine w sulfonamides (TMP/SMZ).